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About the Author
Gina Patel, MPharm, PhD
President and CEO, Patel Kwan Consultancy
Gina Patel, MPharm, PhD
President and CEO, Patel Kwan Consultancy
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Drug Excretion
Why do we want to understand excretion pathways? After a drug has entered the body it will be eliminated via a number of routes however, as the FDA renal guidance states, most drugs are cleared by elimination of unchanged drug by the kidney and/or by metabolism in the liver and/or small intestine. If a drug […]
Distribution
Following drug absorption from the site of administration, drug will enter the bloodstream. From the blood, drug can distribute to various tissues throughout the body. Many drugs do not distribute evenly throughout the body and may preferentially distribute to different organs or tissues. Drug distribution is usually a dynamic process and concentrations in tissues will […]
What is Pharmacokinetics?
In short, the word is derived from “pharmakon” meaning drug and “kineticos” meaning movement. Therefore, pharmacokinetics defines as the movement of drugs in the body. Pharmacokinetics can be thought of as what the body does to the drug. Concentration versus time profile following a single oral dose. Movement of drugs in the body […]