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About the Author
Gina Patel, MPharm, PhD
President and CEO, Patel Kwan Consultancy
Gina Patel, MPharm, PhD
President and CEO, Patel Kwan Consultancy
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Understanding Absorption Processes, BCS Class, and Their Impact on Pharmacokinetics
Introduction Pharmacokinetics is the study of how drugs move through the body, including their absorption, distribution, metabolism, and excretion. Among these processes, absorption plays a crucial role in determining the onset, intensity, and duration of a drug’s effects. In this educational blog, we will explore the intricacies of absorption processes, the Biopharmaceutics Classification System (BCS), […]
Oral Absorption
Following extravascular drug administration, the drug needs to be absorbed into the systemic circulation. Following absorption from the gastrointestinal (GI) tract, the hepatic portal vein passes the drug through the liver, where it undergoes first pass metabolism. For some drugs a large portion of the dose is metabolized by first pass metabolism before the drug […]
Metabolism
Why do we want to understand metabolism? With the rise in polypharmacy it has become important to understand how concomitantly administered drugs will impact each other’s exposure and thus safety and efficacy. In the context of drug development. Metabolism Overview Drugs are metabolized by the body in order to make them easier to be excreted. […]
pH Dependent Drug Interactions with Acid Reducing Agents
Do I Need to Conduct a Clinical Study? Well the answer is, that it depends on certain characteristics of your investigational drug. For immediate release basic drugs that has pH dependent solubility at pH of 1.0-6.8, this can mean that solubility in the stomach can decrease as pH increases. When solubility of the investigational drug […]